What is theElectron Resonance Imaging?

What is the ERI?

 

ERI is an abbreviation for Electron Resonance Imaging. This is a new method of functional imaging that is based on Electron Paramagnetic Resonance.


The ERI technique uses a combination of a suitable magnetic field and the injection of an external spin probe into an animal. Spin probes, that are used in ERI technique, belong to the family of nitroxides or trityls. The physiological environment inside an animal’s body affects the spectral properties of the spin probe, which contains an unpair electron. As a result, it is possible to monitor unique biological parameters such as the absolute level of oxygen, redox state, pH changes and oxidative stress.

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MCP, HMP as examples of spin probes use in Electron Resonance Imaging 

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Areas of application

 

  • Monitoring of oncology therapies and imaging of their effects
  • Diagnosis of neurodegenerative diseases
  • Detection for areas of hypoxia and oxygen concentration, as well as examination of their mechanisms
  • ROS imaging and studies of oxidative stress
  • Whole-body spin probe mapping in small rodents (diameter  up to 34 mm)
  • Imaging of redox state in different brain disorders

Resolution parameters

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 Three 10 mm long bottles with OXO71. 3D rendered images of the surface and distribution of the spin density.

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Picture and reconstruction of a bunch of capillaries filled with marker, inner diameter 0,7mm.

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The results indicate the correct mapping of the skeletal system, with the thickness of which is about 100 µm.

The images obtained with ERI

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doi: 10.1021/acs.jpcc.0c05703.

Imaging of control and tumour mouse in ERI TM600

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Imaging of mouse brain in ERI TM600